How Much Does IV Ketamine Cost in Columbus?
By Lance Demaline • September 24, 2026
Quick Answer: At Optimum TMS, IV ketamine is $450 per session, or $2,400 for a series of six, which works out at $400 per session. It's cash-pay only. Insurance doesn't cover it, and that isn't a plan quirk - ketamine infusions for depression are an off-label use, and insurers generally don't cover off-label treatment. Before you commit to that, it's worth knowing that two related treatments for the same problem, Spravato and TMS, usually are covered.
Ketamine clinic pricing is notoriously hard to pin down. Plenty of websites want you to call before they'll tell you a number. Here are ours, what they include, what else you should budget for, and the comparison most clinics would rather you didn't make.
The prices
$450 per session. A single infusion.
$2,400 for six sessions. $400 per session, saving $300 against booking six individually.
Six is the typical starting series for depression, which is why it's priced as a block. Whether that's the right number for you is a clinical decision made at your consultation, not something to assume from a price list.
Cash-pay only. IV ketamine at Optimum is not billed to insurance.
Why insurance won't cover it
The drug itself has been FDA-approved for decades, but as an anesthetic. Using it intravenously to treat depression is an off-label use: legal, widely practiced, and backed by a body of research, but outside the indication the FDA approved. Insurers generally don't pay for off-label treatment, which is why essentially every ketamine infusion clinic in the country is cash-pay.
Be skeptical of any clinic that implies otherwise. Some will help you submit for the office visit component, which is not the same as the infusion being covered, and it's worth being clear on the difference before you're relying on a reimbursement that doesn't arrive.
What to budget for beyond the price
- A ride home after every session. Ketamine is sedating. You can't drive yourself, and this applies each time, not just the first.
- The rest of your day. Between the infusion, the monitoring period, and how you feel afterward, most people write off the remainder of the day rather than going back to work.
- A consultation fee, if one applies. Ask when you book.\
- Continuing sessions, if you respond. The initial series isn't necessarily the end of the spend. Ask what the maintenance pattern typically looks like and what it costs, before you start, not after.
The comparison worth making before you spend $2,400
If you're considering IV ketamine for treatment-resistant depression, two other options treat the same problem and are usually covered by insurance:
Spravato (esketamine) is a nasal spray derived from ketamine and is FDA-approved for treatment-resistant depression, taken alongside an oral antidepressant. Because it's FDA-approved for this specific use, it's typically covered by most major insurance plans, including Medicare and Medicaid, when criteria are met. Like IV ketamine, you're monitored in-clinic and need a ride home.
TMS is FDA-cleared for depression, also typically covered, involves no medication or sedation, and you drive yourself home afterward.
For a lot of people, the honest sequence is to find out whether you qualify for a covered treatment first, and treat IV ketamine as the option you choose deliberately rather than the one you land on because nobody checked. We'll verify your benefits for TMS and Spravato before you commit to anything, and that check costs you nothing.
Some people still choose the infusion, for reasons that have nothing to do with cost. That's a legitimate decision. It's just better made with the full picture.
What our other self-pay options cost
For context, since people comparing prices usually want the whole picture:
- Accelerated TMS: $7,500, covering 50 sessions over five days. Self-pay only, not insurance-billable.
- TMS for OCD: $10,500 for 29 sessions, self-pay.
Standard TMS for depression and Spravato are the treatments that typically run through insurance rather than out of pocket.
Still weighing your options?
A quick consultation answers more than another hour of reading.

Ways to make it manageable
HSA and FSA funds can generally be used for eligible medical expenses. Your plan administrator is the authority on what qualifies.
CareCredit financing is available, and worth asking about if the series total is the barrier rather than the treatment itself.
Ask about the series rather than paying per session if you're already fairly sure you're doing more than one. The six-session block is the cheaper route.
Questions worth asking any ketamine clinic
Prices vary widely between providers, and a low per-session rate doesn't always mean a lower total. Ask:
- Is the price per infusion, or per package, and how many sessions does the package include?
- Is the consultation billed separately?
- Who is present during the infusion, and what are their credentials?
- Is a psychiatrist involved in deciding whether this is appropriate for me?
- What's the plan if this doesn't work?
- What does maintenance cost, if I respond?
That fourth one matters more than price. Ketamine infusions are a medical treatment for a psychiatric condition, and whether it's the right treatment is a psychiatric question. At Optimum, that assessment sits with Dr. Mark E. Blair, MD, a board-certified psychiatrist, alongside the full range of options rather than just the one being sold.
Why is IV ketamine cash-pay when Spravato is covered?
Spravato is FDA-approved specifically for treatment-resistant depression. IV ketamine for depression is an off-label use of a drug approved for anesthesia, and insurers generally don't cover off-label treatment.
Is the cheaper package worth it if I'm not sure I'll do six?
That depends on what your consultation concludes. Ask before you pay, since the appropriate number of sessions is a clinical decision.
Can I use HSA or FSA money?
Generally yes for eligible medical expenses. Confirm with your plan administrator.
Does the price include the consultation?
Ask when you book. Consultation billing is separate from the infusion rate.
Do I need someone to drive me?
Yes, after every session. Arrange it in advance.
What if I can't afford it?
Then the first thing to check is whether you qualify for TMS or Spravato, which are typically covered by insurance. That check is free and it's the right starting point regardless.





















