What to Expect After Your First Spravato Session
By Lance Demaline • June 26, 2026
Quick Answer: After the monitored observation period at the clinic, you'll head home with a driver - you can't drive for the rest of the day. It's normal to feel tired, foggy, or a little "off" for a few hours, with most of those effects fading by the time you wake up the next morning. Don't read too much into how you feel emotionally after one session; Spravato's effect is tracked over a course of treatment, not judged on day one. Here's what the rest of your day, the next morning, and the weeks ahead typically look like.
You've had your first Spravato (esketamine) session, sat through the observation period, and now you're heading home, wondering what the rest of the day holds. This post picks up right there. If you haven't had your first appointment yet and want to know what happens during the session, start with What to Expect at Your First Spravato Session - this guide is about everything that comes after.
The rest of your first day
The most important practical point: you cannot drive after a Spravato session. That's why you arranged a ride, and it's a firm rule, not a suggestion. Plan to be a passenger for the rest of the day.
Once you're home, the best thing you can do is take it easy. Many people feel drained, spacey, or mildly dreamy for a few hours after the dose as the medication's effects wind down. Some feel more or less normal fairly quickly. Both are within the range of typical. A quiet evening - no big plans, no demanding tasks - is the right call.
What you might feel in the hours afterward
During the session you may have noticed a floating or detached feeling. As the afternoon goes on, that generally continues to fade. In the hours after, some people experience:
- Tiredness or a wish to nap
- Lingering mild dizziness or unsteadiness
- A slightly foggy or slowed-down feeling
- Mild nausea
These tend to be short-lived and ease as the medication clears. The clinic monitors things like blood pressure during your observation period specifically, so you leave when it's appropriate, which is part of why the in-office monitoring exists.
If something feels more intense or lasts longer than you expected, that's worth a call to the clinic rather than something to tough out alone.
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The next morning
For most people, the next day is back to baseline. After a full night's sleep, the foggy, tired feeling has usually lifted, and you can drive again and return to your normal routine.
If you're still feeling significantly off the next day, let your care team know. It's useful information for them, and they'd rather hear it than have you wait and wonder.
"Should I feel better already?"
This is the question most people are really asking, so here's the honest answer: one session is not a fair test.
Some people notice early shifts in mood within the first session or two. For others it takes several weeks of consistent treatment before changes show up. Neither timeline means the treatment is or isn't working for you - responses genuinely vary, and a single appointment doesn't tell you much. Your provider tracks your response across the full course and adjusts the plan based on how you're actually doing, not on one data point.
It also cuts the other way. Feeling rough or flat after your first session doesn't mean Spravato has failed you. Give the course the chance to do what it's designed to do, and keep your team in the loop.
Practical tips for after your sessions
- Line up your rides ahead of time for the whole week, not session by session.
- Keep your evenings light on treatment days — plan rest, not errands.
- Follow the clinic's guidance on eating and medications around your appointments.
- Don't stop your other treatments on your own. Many people continue antidepressants or other care alongside Spravato; any change is a decision to make with your provider.
- Jot down how you feel between sessions. A few notes on your mood, sleep, and energy give your team something concrete to work with.
When to call your care team
Most after-session effects are mild and fade on their own. But contact your clinic promptly if you notice a clear, sustained worsening of your mood, side effects that don't settle, or anything that worries you.
If you're having thoughts of harming yourself or feel unable to stay safe, treat it as urgent. Reach your care team right away, and in the U.S. you can call or text 988 to reach the Suicide and Crisis Lifeline, or go to your nearest emergency room. Reaching out is the right move during treatment, not an overreaction.
Can I drive the next day?
Generally yes, after a full night's sleep. You can't drive on the day of treatment, but most people are clear to drive the following day. Follow whatever guidance your clinic gives you.
Can I go back to work after a session?
Not the same day — plan to rest after treatment. Many people return to work the next day. How treatment days fit around your schedule is worth discussing with your provider early on.
Will I feel "high" or out of control?
You may feel temporarily detached or dreamlike during and shortly after the session, but you stay awake and aware, and the effect fades. The monitoring period is there to keep you safe while it does.
What if I didn't feel anything, or felt worse?
Both happen, and neither tells you much after one session. Spravato's effect is judged over a course of treatment. Share your experience with your provider so they can factor it into your plan.
Do I keep taking my antidepressant?
Often yes - Spravato is frequently used alongside other treatments. But don't change anything without talking to your provider first.




















