What Is IV Ketamine Therapy? A Patient's Guide
By Lance Demaline • June 26, 2026
Quick Answer: IV ketamine therapy is a monitored, in-office infusion used to treat depression and certain other conditions that haven't responded well to standard medications. It works differently from typical antidepressants and tends to act faster, but it's used off-label, isn't covered by insurance, and requires a clinical evaluation to see if you're a candidate. This guide covers how it works, what a session is like, what it costs, and who it's for.
If you've reached this page, you've probably already tried antidepressants and talk therapy without getting all the way to where you want to be. IV ketamine is one of the options clinicians turn to in that situation. It gets talked about a lot online, often with more hype than detail, so this guide sticks to what it actually is and what to expect.
What is IV ketamine therapy
Ketamine is a medication that's been used safely in hospitals as an anesthetic for decades. At lower doses than those used in surgery, it has shown promise for treating mood conditions, and that's how it's used here: as a controlled infusion delivered through an IV while you're monitored by clinical staff.
It's important to be clear about one thing up front. Ketamine is FDA-approved as an anesthetic, but it is not FDA-approved specifically for depression. When it's used for depression, that's an off-label use - which is legal, established, and common in psychiatry, but different from a depression-specific approval. (Spravato, a related nasal-spray medication, does carry that approval; you can read how the two compare in our IV Ketamine vs. Spravato vs. TMS guide.)
How it works
Most common antidepressants act on serotonin and can take weeks to build up before you feel anything. Ketamine works through a different pathway in the brain - the glutamate system - and is thought to help support new connections between brain cells. That different mechanism is why many people notice changes on a faster timeline than they would with a standard antidepressant.
Individual responses vary, and ketamine isn't a cure or a one-time fix. For most people, it's part of a broader treatment plan rather than a standalone solution.
Still weighing your options?
A quick consultation answers more than another hour of reading.

What a session is actually like
This is the part most patients want to know, so here's the practical version.
You'll be in a comfortable chair in the clinic with the infusion running over a controlled period, monitored by staff the whole time. During the session, it's common to feel a floating or dreamlike sensation and some shift in how you perceive time, your body, or your surroundings. That effect is expected, it's temporary, and it fades as the session ends.
Because of those effects, you can't drive afterward. You'll need someone to drive you home. Plan for the appointment to take longer than the infusion itself, since there's a short recovery and observation period before you leave.
You don't need to do anything elaborate to prepare beyond following the instructions the clinic gives you ahead of time, which typically include guidance on eating beforehand and arranging your ride.
What a typical course looks like
IV ketamine usually isn't a single appointment. The initial phase is generally a series of sessions spaced out over a couple of weeks rather than one infusion. At Optimum, that initial series is structured as six sessions.
After that, some people do periodic maintenance sessions to hold onto their progress, while others don't need them. Your provider will base that on how you respond, not on a fixed schedule.
What it costs, and why insurance doesn't cover it
Here's the honest part. Because IV ketamine is used off-label, it generally can't be billed to insurance - including at Optimum, where it's self-pay only.
The current self-pay rates are $450 per session, or $2,400 for a six-session series (which works out to $400 per session). CareCredit financing is accepted if you'd rather spread the cost out.
If cost is a deciding factor, it's worth knowing that two related treatments - TMS and Spravato - are typically covered by most major insurance plans. Whether one of those is a better fit is exactly the kind of thing a consultation sorts out.
Is it safe?
Ketamine has a long track record in medical settings, and the supervised, low-dose approach used here is designed with safety in mind. You're monitored throughout, which is part of why it's done in the clinic rather than at home.
Side effects are usually short-lived and tied to the session itself - things like temporary changes in perception, mild nausea, dizziness, or shifts in blood pressure that the clinical team watches for. They typically resolve as the medication clears.
That said, ketamine isn't right for everyone, and certain medical histories make it a poor fit. That's not something to self-assess from a blog post, which is the whole reason candidacy is determined through a clinical evaluation.
Who's a candidate
IV ketamine is generally considered for adults with depression or certain other conditions that haven't responded adequately to other treatments. Whether it's appropriate for you depends on your full history, your current medications, and a medical evaluation - some conditions are reasons to avoid it entirely.
The practical takeaway: nobody can tell you over the internet whether this is right for you. A consultation can.
Is IV ketamine the same as Spravato?
No. They're related but distinct. Spravato (esketamine) is an FDA-approved nasal spray for treatment-resistant depression and is usually covered by insurance. IV ketamine is an infusion used off-label and is self-pay. The delivery, FDA status, and coverage all differ.
Will I be unconscious or sedated?
No. This is a much lower dose than the anesthetic doses used in surgery. You stay awake and aware, though you'll likely feel altered during the session. You won't be put under.
How soon might I notice a difference?
Some people notice changes sooner than they would with a traditional antidepressant, but timing varies from person to person and there's no guaranteed timeline. Your provider can set realistic expectations for your situation.
Can I drive myself home afterward?
No. You'll need a ride home after every session because of the temporary effects of the medication.
Do I have to stop my current antidepressant?
Not necessarily. Many people continue other treatments alongside ketamine, but that's a decision your provider makes based on your specific medications and history.




















